did james hetfield smoke cigarettes Drunk James partying at the Ruthies Inn Found this absolute gem :

Other factors that may increase the chances of developing smokers leg include: smoking being over the age of 60 years having overweight or obesity diabetes high blood pressure high cholesterol a family history of PAD, heart disease, or stroke chronic kidney disease or being on dialysis Many people with smokers leg experience no signs or symptoms

10.1016/S0092-8674(00)80358-X

Laboratory safety evaluation of lokivetmab, a canine anti-interleukin-31 monoclonal antibody, in dogs

[6] US Patent Database (Justia)

Both animal and human studies have demonstrated that an adverse intrauterine environment can lead to HPA axis dysfunction [40, 41]