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Because it has an autoregulatory negative feedback loop between p53 and MDM2, toxicant-induced p53 overactivation might enhance MDM2 expression, and thereby promote Akt phosphorylation and inhibit Pim phosphorylation in hepatocytes, which contributed hepatocytes to survival in toxicant-induced hepatic inflammation 26

Tan's research has been published in multiple medical and scientific journals, including

However, a form known as vitamin E acetate has been found to exist in both nicotine and non-nicotine e-cigarettes, and is associated with lung injury related to e-cigarette or vape product use (EVALI), which may be permanent