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Dedifferentiated RPE had globally decreased chromatin accessibility and expression of genes linked to hallmarks of aging. Notably, young, dedifferentiated RPE also exhibited a compensatory upregulation of hallmarks of aging-related genes including mitochondrial function and proteostasis while aged dedifferentiated RPE did not, which decreased their survival following CSC treatment, as experimentally verified with TUNEL labeling

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Nevertheless, we did manage to validate the proposed differentiated roles of the left and right vmPFC GMV in addictive behaviour (i.e., with initiation and sustenance/dependence respectively) in daily smokers from the independent HCP data