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The IDH3 isoforms are the primary mitochondrial enzymes responsible for oxidative decarboxylation of isocitrate within the context of the TCA cycle

Similarly, mutations in the ATP13A2 gene associated with PD result in widespread lysosomal impairment, characterized by membrane instability, impaired acidification, reduced processing of lysosomal enzymes, and diminished degradation of substrates and autophagosomes [118]

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For example, for claims with dates of service between October 1, 2026, through December 31, 2026, covered entities that choose to submit data elements from Part D 340B claims would submit the data to the 340B repository no later than March 31, 2027