Critical Rev Food Sci Nutr 60(4):597625 Acknowledgements I would like to extend my sincere appreciation to Centre of Neurodisease research, zebrafish lab, MIET Meerut for their invaluable assistance throughout the production of this essay
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In this review, we explore the current understanding of lipedema through clinical, tissue, and cellular lenses, and examine suspected pathological mechanisms, including hormonal influences (such as estrogen), adipocyte hypertrophy and hyperplasia, increased extracellular matrix (ECM) fibrosis, and specialized immune cell involvement, including M2 macrophage infiltration
