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Either degradation of the internalized receptors without recycling or downregulation of receptor gene transcript reduces receptor density on the cell surface plasma membrane without a change in receptor affinity [15, 25], which then even elicit shrinkage of cell volume [18, 26]

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however, such techniques remain technically demanding and restricted to superficial tissues ( Statements Author contributions FM: Conceptualization, Investigation, Writing original draft, Writing review and editing

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