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We find that drugs which inhibit generation of glutamate by the glutathione cycle elicit decreases in cytosolic glutamate and decreased miniature excitatory post synaptic potential (mEPSC) frequency

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For danuglipron, most AE were mild in severity at the phase 2 trial for people with T2D, but 2234% of participants receiving the higher doses (80 mg twice daily) discontinued the medication due to AE (vs

Hydrogen peroxide removes TRPM4 current desensitization conferring increased vulnerability to necrotic cell death