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The MAPEG superfamily of microsomal GSTs consists of subgroups designated I-IV, between which amino acid sequences share less than 20% identity

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We first performed a thermal stability assay by incubating the enzymes at different temperatures and then measuring enzyme activities via oxidation of ABTS, a commonly-used laccase substrate 32

In the in vivo PD-L1 target occupancy model, oral dosing of ALG-094103 at 50 mg/kg demonstrated higher PD-L1 target occupancy than oral dosing of INCB086550 at 150 mg/kg and IV dosing of durvalumab at 5 mg/kg