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FOXO4-DRI has a rapidly expanding and high-impact published research base, with studies published across Nature, Nature Communications, Communications Biology, Aging, Frontiers in Bioengineering and Biotechnology, and PMC since its foundational description in 2017

This issue has been vigorously debated because of examples in the literature, where peripheral measures either failed to adequately reflect central pathophysiology or did not serve as reliable biological markers

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Maina JG, Balkhiyarova Z, Nouwen A, Pupko I, Ulrich A, Boissel M, et al