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The activation of estrogen receptor leads to increased expression of cyclins, and prompts cancer cells to transition from the quiescent phase to the proliferative phase 31 , leading to tumor growth and development

Upon binding to estrogen, ER translocates to the nucleus where it binds to DNA regions containing estrogen-responsive elements (ERE) and subsequently regulates the transcription of numerous genes that are crucial for breast tumorigenesis [4]

The organ support phase addresses tissue damage and recovery, complementing the immune modulation of earlier phases

Supplied in a 500 ml bottle, VB12 is easy to store and administer

doi: 10.1016/j.vph.2018.02.010