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These hit hardest when you first start and when your dose goes up

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multiple agent therapy including but not limited to wherein each agent is independently a sub-therapeutic dose, with either sequential or concurrent administration of the agents, will produce the desired pharmacological response, such as an erection sufficient for sexual intercourse, in patients with nerve damage, such as resulting from a prostatectomy or spinal cord injury, who are marginally responsive to a PDE-5 inhibitor such as sildenafil