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[50] [51] [52] Since most benzodiazepines are highly selective GABA A positive allosteric modulators, the anxiolytic effect mediated by increased GABAergic activity is stronger than alcohol, which binds to numerous other receptors and has poor selectivity as a GABAergic agent, and alcohol even acts as a negative allosteric modulator of NDMA receptors, which likely contributes to its impairing and euphoric effects, along with numerous other target receptors

(Daryl is his middle name, which NPR and Kaiser Health News are using to protect his identity because it is illegal to use buprenorphine without a prescription.) Weeks later, the grind of chasing heroin had worn on him