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To identify IGF-1-mediated miRNA regulatory networks that cause temozolomide (TMZ) to be insensitive to glioblastoma multiforme treatment, on the basis of comprehensive analysis of multiple databases and in vitro experiments, Chen et al (104) confirmed that IGF-1 upregulated miR-513a-5p signaling reduced the sensitivity of glioma cells to TMZ by inhibiting the NEDD4L-inactivated Wnt/-catenin pathway

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Chronic sleep deprivation accelerates Sleep Glymphatic System Clears Brain Waste During Deep Sleep During deep sleep, the glymphatic system clears metabolic waste from the brain including beta-amyloid associated with Alzheimer's disease

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