One of the important members of the vitamin B complex is vitamin B12, the only vitamin containing a metallic element, namely cobalt
The combination of low B12 and elevated folate is particularly suggestive of small intestinal bacterial overgrowth
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It is being studied for its potential effects on metabolism, including increased energy expenditure, fat loss, and cellular aging, by boosting cellular NAD+ levels
While the IOM had based B12 needs on the amount required to correct hematological parameters for people with pernicious anemia, the EFSA had almost 20 more years of research to draw on, and concluded that the most suitable approach was basing needs on biomarkers (serum B12, holotranscobalamin, MMA, and homocysteine)