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The trial included roughly 450 adults with obesity or who were overweight and had knee osteoarthritis

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Pre-clinical studies have demonstrated mixed findings, including potential protective effects of GLP-1 RAs in the context of diabetic retinopathy, with GLP-1 receptors found in the RPE serving a neuroprotective role in conditions of high glucose

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Importantly, P5-induced cAMP production was inhibited by the selective GLP-1R antagonist Ex 939 in a concentration-dependent manner (Supplementary Fig