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NCT03819153) was a multicenter, double-blind, randomized (stratified according to the use of sodium-glucose cotransporter 2 [SGLT2] inhibitors at baseline), placebo-controlled clinical trial led by an academic steering committee and conducted at 387 international sites, with a median follow-up of 3.4 (interquartile range 2.94.0) years

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-aminobutyric acid from Lactobacillus reuteri alleviates pathology by activating the Akt/GSK3/GPX4 axis (129), emodin upregulates the mitochondrial protein ubiquitin-cytochrome C reductase core protein 1 to suppress ferroptosis (130) and corilagin protects neurons by regulating the Toll-like receptor 4/Src/NOX2 pathway (131)