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For the efficacy estimand, the corresponding change in mean body weight with 5-mg tirzepatide was 6.2 kg, 10-mg tirzepatide was 8.2 kg, and 15-mg tirzepatide was 10.9 kg vs 1.7 kg with placebo (5 mg: difference, 7.8 kg [95% CI, 9.4 to 6.3]
However, during illness or injury, the body may not be able to produce enough of it
Weight loss with semaglutide was accompanied by greater improvements than placebo with respect to cardiometabolic risk factors, including reductions in waist circumference, blood pressure, glycated haemoglobin levels, and lipid levels