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As class B1 peptide agonists engage their receptors via a two-domain interaction, their efficacy for G protein-mediated signalling is influenced by multiple factors, including the nature of interactions with the ECD and TMD, contributing to both peptide affinity and how ligandreceptor interactions influence G protein binding, nucleotide exchange and G protein dissociation from the receptor

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Taurine addresses cardiac protection and cellular aging through pathways distinct from mTOR inhibition (rapamycin), NAD+ restoration (NMN), or senolytic clearance (Fisetin)