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Therapeutically, monoaminergic antidepressants alone are often insufficient in LLD, likely due to reduced synaptic plasticity and broader neurobiological rigidity

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Titrate more slowly than the standard schedule if needed, prioritizing milk supply maintenance over aggressive weight loss

The standard dose escalation begins at 2.5 mg subcutaneously once weekly for four weeks, followed by increases to 5 mg, 7.5 mg, 10 mg, 12.5 mg, and finally 15 mg at four-week intervals as tolerated

The SUSTAIN-7 trial compared the effectiveness of low-dose semaglutide (1mg/weekly) to low-dose dulaglutide (1.5mg/weekly) in study volunteers with T2D