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Additionally, saffron treatment led to improved neurological scores, suggesting its efficacy in mitigating ischemic damage [15,46,58]

Furthermore, following the 2008 US Food and Drug Administration (FDA) guidance for industry that requires proof of cardiovascular safety as a prerequisite for approval of diabetes treatments, there has been a substantial increase in the understanding of the risks of these treatments, in addition to their benefits, on clinically relevant outcomes

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