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In the NOR test, the HACE mice took significantly longer to recognize a new object, clearly demonstrating that exosomes from HACE patients negatively affected their learning, memory, and cognitive functions (Fig

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Indeed, Pink1-KO mice, a model that is typically asymptomatic of PD and void of dopaminergic degeneration, exhibited a pronounced reduction in the density of tyrosine hydroxylase-positive neurons in the dorsal and ventral striatum and dopamine transporters following infection by a pathogenic Gram-negative bacterium, Citrobacter rodentium (Matheoud et al., 2019)

The above-treated cells were gently washed with PBS and stained with 200 L of Calcein AM and propidium iodide (PI

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