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The prescribing decision should be based on a comprehensive evaluation including BMI calculation, assessment of weight-related comorbidities, previous weight loss attempts, and screening for contraindications

Supplementary Materials Data Availability Statement The datasets generated and/or analysed during the current study are available from the corresponding author on reasonable request.

According to previous studies by Park et al (121) and Lee et al (122), terrein, a novel fungal metabolite reduces TYR expression by downregulating MITF in a manner that is dependent on ERK activation, with its inhibitory effects on melanin synthesis prolonged by ubiquitin-mediated proteasomal degradation

Metabolism reflects how efficiently your body can: use glucose respond to insulin regulate hunger and fullness store and release fat recover from stress absorb nutrients from food A healthy metabolism depends heavily on: gut function hormonal balance liver health stable blood sugar patterns adequate nutrient intake This is why two people can eat similar foods and experience completely different outcomes

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