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DISCUSSION To the best of our knowledge, this study is one of the first to compare the impact of vaping the European JUUL version and cigarette smoking on peripheral and central hemodynamics and arterial stiffness 37-41

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Because these cigarette health warnings, as shown through the robust scientific evidence described in detail in sections VI-VII, are factual and accurate, advance the substantial Government interest in promoting greater public understanding of the negative health consequences of smoking, and are not unduly burdensome, FDA believes the warnings would pass a First Amendment analysis under Zauderer v

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