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Changes in the expression of muscle-related proteins, such as Atrogin-1, MuRF-1, and Mfn-2, were consistent with the muscle preservation effect of BPC157

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FDA has raised regulatory and safety concerns regarding certain BPC-157-related bulk substances used in compounding contexts, and the dietary supplement classification of BPC-157 products has been a topic of industry discussion through 2025 and into 2026

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