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GLP1R , the GLP-1 receptor gene these compounds target, is joined by FTO (the fat-mass and obesity-associated gene), MC4R (a melanocortin receptor central to satiety and energy balance), and TCF7L2 (a transcription factor tied to glucose homeostasis and GLP-1 secretion)

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10.1038/s41467-017-01701-2 Nat

However, like other TKIs, lenvatinib often causes adverse drug reactions such as hypertension, diarrhea, proteinuria, and fatigue, which may lead to dose interruption or discontinuation (Kudo et al., 2018), (Kim et al., 2021)

Orlistat should not be used during pregnancy or breastfeeding