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Women and people who are assigned female at birth who have excess weight have a higher incidence of menstrual dysfunction and anovulation

In vitro evidence demonstrates that MI enhances mitochondrial biogenesis and normalizes mitochondrial ultrastructure in oocytes from PCOS animal models, counteracting ROS-mediated mitochondrial depolarization and DNA damage

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There is evidence that metformin can cross the bloodbrain barrier and localize in several brain areas ( As with other animal models with metabolic dysfunction, MSG-rats have high parasympathetic and low sympathetic activity

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