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However, extrapolating these findings to human physiology is problematic due to significant species differences in pancreatic anatomy, GLP-1 receptor distribution, and metabolic responses

When you begin losing weight, your body makes biological adjustments in response to the sudden changes

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Traditional pairwise meta-analyses, which group various medications together, yield an overall efficacy but lack the specificity needed for individual comparisons, leading to heterogeneity among the medications and diluting statistical significance

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