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The restoration of biomechanical properties demonstrated in animal ligament models suggests potential for improved outcomes compared to rest and splinting alone

By using 1,1-dioctadecyl-3,3,3,3-tetramethylindotricarbocyanine iodide (DiR), a near IR fluorescent and hydrophobic carbocyanine, as a fluorescence tracking agent, whole body imaging demonstrated that COXP micelles delivered DiR to mouse brains about 20 times higher than DiR administered alone [52]

This disruption promotes enhanced diffusion of the encapsulated drug across the skin barrier [313, 314]

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Schfer, et al