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Visible body composition changes typically emerge around week 3-4, with significant fat loss and waist circumference reduction becoming apparent by weeks 5-8

These changes are minor and do not last long

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Nauck MA, DAlessio DA (2022) Tirzepatide, a dual GIP/GLP-1 receptor co-agonist for the treatment of type 2 diabetes with unmatched effectiveness regarding glycaemic control and body weight reduction