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Oron et al

Secondary analysis of renal end points in a cardiovascular safety trial of a DPP-4 inhibitor in patients with T2DM at high cardiovascular risk, showing that saxagliptin reduces albuminuria in a glucose-independent manner

Example weekly schedule (30mg vial) Week 1: 2.5mg dose Reconstitute 30mg vial with 3ml water Monday: Inject 0.25ml (25 units) Vial contains 29 doses of 2.5mg remaining Refrigerate, use over next 11 weeks Week 2-4 : Continue 0.25ml weekly Week 5 : Increase to 0.5ml (50 units) for 5mg dose Week 9 : New vial or continue (depending on dose progression) Dosing 40mg vials 40mg vials are bulk option

Here, we propose an allosteric targeted drug delivery strategy that targets classical BBB transmembrane receptors by designing peptide ligands that specifically bind to their transmembrane domains

Among the array of chemotherapeutics, methotrexate and 6-mercaptopurine are used during the maintenance phase of ALL treatment, both of which are implicated in hepatotoxicity